Nocturia can have a real impact on your patients

Nocturia affects 40 million adults in the United States1,2

Over 15% of men and 20% of women above the age of 20 wake up 2 or more times per night to void, and the prevalence increases with age.3 But we do not have to just accept that it is a normal part of getting older.4

Prevalence of nocturia by gender and age3
Number of voiding episodes per night
Men
1 episode1 episode
2 episodes2 episodes
3+ episodes3+ episodes
Women
1 episode1 episode
2 episodes2 episodes
3+ episodes3+ episodes

While nocturia can occur along with other conditions, it is a distinct condition.


Some associate nocturia with other lower urinary tract symptoms, so it is often seen as a secondary symptom. However, nocturia should be evaluated independently to determine treatment requirements.5

Nocturia impacts sleep, which can lead to effects on everyday life

Sleep disturbances due to nocturia have been shown to impair functioning, quality of life, overall health, and productivity.5

Patients who awoke at least 3 or 4 nights per week had significantly higher rates of moderate daytime sleepiness, naps, and sick leave than those who awoke fewer than 3 nights per week.6

Nocturia affects millions of patients in the U.S.

Sick leave increases with nocturnal awakenings.


Percentage of patients who reported taking sick leave6

Nocturia can worsen health

Nocturia has been associated with increased rates of depression in both men and women, particularly in younger age groups.

Patients with nocturia may experience higher rates of depression7
Men
With nocturia
Without nocturia
Women
With nocturia
Without nocturia

Reduced sleep duration and quality can impact cognitive and physical function and have been associated with adverse health outcomes, including an increased risk of7-9:

Nocturia can worsen health

Watch Evelyn’s story to see how nocturia impacts her life.

Nocturia costs more than just sleep

The costs of nocturia are even higher than for other conditions like benign prostatic hyperplasia (BPH) and overactive bladder (OAB).9

Estimated total cost (billions of dollars/year)9

Nocturia
Urinary incontinence
OAB

$61 billion9
Estimated indirect cost due to loss of productivity and sick leave associated with nocturia

Nocturia increases patients’ risk for falls

Direct cost as a result of falls
$1.5 billion9

Nocturia increases patients’ risk for fractures

Increased risk of fall-related fracture
2.2x higher9

In most cases, nocturia is caused by nocturnal polyuria

In up to 88% of cases, nocturia is caused by nocturnal poluyuria
  • In a randomized clinical trial, nocturnal polyuria was the cause of nocturia in 88% of cases, based on patients who completed a frequency-volume chart10,11
  • Patients were excluded from the trial if they had congestive heart failure, uncontrolled hypertension, uncontrolled diabetes mellitus, renal insufficiency, or other relevant comorbidities*
  • Nocturia with nocturnal polyuria
  • Nocturia without nocturnal polyuria

Nocturnal polyuria occurs when the kidneys overproduce urine at night.12


  • The condition occurs due to reduced vasopressin secretion at night5
  • Vasopressin is a naturally occurring antidiuretic hormone that concentrates urine and reduces urinary output5
  • Data from a randomized clinical trial. Patients were excluded from the trial if they had any of the following conditions: congestive heart failure, uncontrolled hypertension, uncontrolled diabetes mellitus, renal insufficiency, hepatic/biliary disease, current/past urologic malignancy, active urinary tract pathology, severe pelvic prolapse, neurogenic detrusor overactivity, global polyuria (urinary output >40 mL/kg/24 hours indicated by a 3-day voiding diary during screening), a history of diabetes insipidus, polydipsia, obstructive sleep apnea requiring therapy, hyponatremia, or syndrome of inappropriate antidiuretic hormone (SIADH) secretion.

OAB and BPH medications don’t target nocturnal polyuria specifically

Kidney
Bladder
Prostate
  • OAB and BPH medications target the bladder and prostate, respectively, so treating nocturnal polyuria with those medications addresses only part of the problem12
  • In many cases, behavioral changes (like reduced fluid intake before bed) won’t address the underlying cause of nocturnal polyuria

When nature calls too often at night it can have a real impact for millions of patients

Nocturia leads to far more than interrupted sleep.

  1. Health issues, including obesity, cardiovascular disease, and depression7,8
  2. Lost productivity and more sick days5,6
  3. Increased financial burden for both patients and employers9

BPH and OAB medications don’t target the kidneys.12


In up to 88% of nocturia cases, nocturnal polyuria, an overproduction of urine in the kidneys at night, is present. So medications targeting the prostate or bladder may not be enough.10,11

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