Nocturia affects 40 million adults in the United States1,2
Over 15% of men and 20% of women above the age of 20 wake up 2 or more times per night to void, and the prevalence increases with age.3 But we do not have to just accept that it is a normal part of getting older.4
While nocturia can occur along with other conditions, it is a distinct condition.
Some associate nocturia with other lower urinary tract symptoms, so it is often seen as a secondary symptom. However, nocturia should be evaluated independently to determine treatment requirements.5
Nocturia impacts sleep, which can lead to effects on everyday life
Sleep disturbances due to nocturia have been shown to impair functioning, quality of life, overall health, and productivity.5
Patients who awoke at least 3 or 4 nights per week had significantly higher rates of moderate daytime sleepiness, naps, and sick leave than those who awoke fewer than 3 nights per week.6
Sick leave increases with nocturnal awakenings.
Nocturia can worsen health
Nocturia has been associated with increased rates of depression in both men and women, particularly in younger age groups.
Reduced sleep duration and quality can impact cognitive and physical function and have been associated with adverse health outcomes, including an increased risk of7-9:
Nocturia costs more than just sleep
The costs of nocturia are even higher than for other conditions like benign prostatic hyperplasia (BPH) and overactive bladder (OAB).9
Estimated total cost (billions of dollars/year)9
In most cases, nocturia is caused by nocturnal polyuria
- In a randomized clinical trial, nocturnal polyuria was the cause of nocturia in 88% of cases, based on patients who completed a frequency-volume chart10,11
- Patients were excluded from the trial if they had congestive heart failure, uncontrolled hypertension, uncontrolled diabetes mellitus, renal insufficiency, or other relevant comorbidities*
- Nocturia with nocturnal polyuria
- Nocturia without nocturnal polyuria
Nocturnal polyuria occurs when the kidneys overproduce urine at night.12
- Data from a randomized clinical trial. Patients were excluded from the trial if they had any of the following conditions: congestive heart failure, uncontrolled hypertension, uncontrolled diabetes mellitus, renal insufficiency, hepatic/biliary disease, current/past urologic malignancy, active urinary tract pathology, severe pelvic prolapse, neurogenic detrusor overactivity, global polyuria (urinary output >40 mL/kg/24 hours indicated by a 3-day voiding diary during screening), a history of diabetes insipidus, polydipsia, obstructive sleep apnea requiring therapy, hyponatremia, or syndrome of inappropriate antidiuretic hormone (SIADH) secretion.
OAB and BPH medications don’t target nocturnal polyuria specifically
- OAB and BPH medications target the bladder and prostate, respectively, so treating nocturnal polyuria with those medications addresses only part of the problem12
- In many cases, behavioral changes (like reduced fluid intake before bed) won’t address the underlying cause of nocturnal polyuria
When nature calls too often at night it can have a real impact for millions of patients
Nocturia leads to far more than interrupted sleep.
BPH and OAB medications don’t target the kidneys.12
In up to 88% of nocturia cases, nocturnal polyuria, an overproduction of urine in the kidneys at night, is present. So medications targeting the prostate or bladder may not be enough.10,11